報(bào)告題目：A delay differential equation model for metabolic feedback among glucose, insulin and glucagon, and some thoughts on?dual pump artificial pancreas

報(bào)告時(shí)間：2024年6月28日（周五）上午10：00

報(bào)告地點(diǎn)：9號(hào)樓景中師范中心

報(bào)告人：李嘉旭

報(bào)告人單位：路易維爾大學(xué)

報(bào)告人簡(jiǎn)介：

李嘉旭，博士，美國(guó)路易維爾大學(xué)教授。1996年獲美國(guó)亞利桑那州立大學(xué)計(jì)算機(jī)科學(xué)碩士學(xué)位，2004年獲美國(guó)亞利桑那州立大學(xué)數(shù)學(xué)博士學(xué)位。自2007年8月起在美國(guó)路易維爾大學(xué)數(shù)學(xué)系任助理教授，副教授，教授。李嘉旭教授主要從事于動(dòng)力系統(tǒng)、泛函微分方程和數(shù)學(xué)生物學(xué)的研究，特別集中于基因轉(zhuǎn)化，代謝系統(tǒng)及糖尿病的研究，任Frontier Systems Biology和Mathematical Bioscience and Engineering編委。在主要專業(yè)雜志發(fā)表有影響力的多篇論文，參與美國(guó)衛(wèi)生研究院、能源部項(xiàng)目，并主持其子項(xiàng)目。研究成果處于國(guó)際領(lǐng)先水平，被生物學(xué)家和控制專家所應(yīng)用。在2007年8月之前，李嘉旭教授曾在美國(guó)高科技工業(yè)領(lǐng)域工作十余年，歷任程序員、工程師、高級(jí)工程師、資深高級(jí)工程師，從事數(shù)據(jù)庫(kù)和控制軟件的研發(fā)工作。

報(bào)告主要內(nèi)容：

Glucose, insulin, and glucagon together form a complete endocrine metabolic feedback loop. Most existing modeling work pertaining to this loop focuses mainly on the regulations between glucose and insulin. The role of glucagon in these works is summarized by hepatic glucose production(HGP) dependent solely on insulin levels. In this talk, we carefully analyze the secretion of glucagon, its role in HGP, and its interactions with insulin, and then formulate a dynamical system model to further analyze its effects in balancing blood sugar levels. The presence of glucagon allows us to examine the impacts of HGP governed by insulin and glucagon separately. This reveals insight about how a very recent concept, glucagon resistance, can affect blood glucose levels and lead to rampant glucagon production and consequently blood sugar levels. We also show that a form of insulin resistance in hepatic cells can lead to excess insulin secretion, a characteristic of type 2 diabetes mellitus. We also present some thoughts on modeling the feedback loop in a dual pump artificial pancreas.

??邀請(qǐng)單位：數(shù)學(xué)與統(tǒng)計(jì)學(xué)院